FAQ
The questions we get. Answered directly, without hedging.
The Product
Q: What is Clera?
Clera is a daily oral supplement in chewable tablet form designed to support enamel mineral density, oral microbiome balance, and gum tissue health. It contains a targeted blend of Xylitol (DC), Guava Fruit Powder, a 3-strain oral probiotic blend (Lactobacillus salivarius LS97, Lactobacillus paracasei LC86, Lactobacillus acidophilus LA85), and Microcrystalline Hydroxyapatite Complex. Take one tablet after a meal, daily. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Q: How do I use Clera?
Chew one tablet after a meal, once daily. "After meals" is intentional — post-meal is when oral pH drops as bacteria metabolize food sugars, and when enamel is most susceptible to demineralization. This is the highest-value window for both xylitol's acid-neutralizing effect and hydroxyapatite's remineralization activity.
Q: Is Clera a replacement for brushing and flossing?
No. Clera complements mechanical hygiene — it does not replace it. Brushing removes plaque physically. Clera works at the biochemical and microbiological level: modulating the chemistry of the oral environment and the composition of the microbial community. Both matter. Neither substitutes for the other.
Q: What does Clera taste like?
The tablet contains Natural Flavors and Xylitol DC, which has a clean, mild sweetness without the chemical aftertaste associated with artificial sweeteners. The overall profile is designed for a pleasant chewing experience that supports daily compliance.
Q: Where is Clera manufactured?
Clera is manufactured in the USA in a facility following cGMP (Current Good Manufacturing Practice) standards.
Q: How long until I notice results?
Oral microbiome shifts and enamel remineralization are gradual, cumulative processes — not single-dose events. Most published oral probiotic studies observe measurable changes in microbial populations over 4–12 weeks of consistent daily use. Clera is designed for daily, ongoing use as part of a routine. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
The Ingredients
Q: Why xylitol instead of a regular sweetener?
Because xylitol is not a passive sweetener — it is an active cariostatic agent. It is the only sweetener that Streptococcus mutans will attempt to metabolize and fail, producing a dead-end toxic metabolite in the process. No other common sweetener in supplement formulation has this mechanism. It also serves as the tablet's chewable base, making it both active ingredient and functional excipient. These statements have not been evaluated by the FDA.
Q: Why hydroxyapatite at 5mg? That seems low.
The effective dose for hydroxyapatite in oral applications is governed by ion availability at the enamel surface, not bulk absorption. In aqueous contact with saliva, even a small mass of microcrystalline hydroxyapatite releases a significant local concentration of Ca²⁺ and PO₄³⁻ ions at the tooth surface during chewing. This is a topical mechanism, not a systemic one — delivery efficiency matters more than total mass. These statements have not been evaluated by the FDA.
Q: Why three probiotic strains? Why not more?
Three strains were selected because each addresses a distinct and documented oral mechanism: LS97 for biofilm structural disruption, LC86 for competitive exclusion and bacteriocin production, LA85 for microbiome and salivary environment modulation. Adding strains beyond specific mechanistic rationale dilutes the dose per strain without adding new mechanisms. More strains is not more effective. These statements have not been evaluated by the FDA.
Q: What is Guava Fruit Powder doing in a dental supplement?
Addressing gum tissue — which standard dental supplement formulas ignore. The polyphenols in Psidium guajava are clinically documented for anti-inflammatory activity on gingival tissue, and the vitamin C content supports collagen synthesis in the periodontal ligament. At 325mg, it is the largest active dose in the formula. The teeth and the tissue around them are the same system. These statements have not been evaluated by the FDA.
Q: What is Beta-Cyclodextrin and why is it in there?
Beta-Cyclodextrin is an encapsulation excipient — a ring-shaped oligosaccharide that forms stable complexes with lipophilic molecules. In Clera's formula, it protects sensitive active compounds (probiotics, polyphenols) from degradation during tablet shelf life and ensures consistent release during chewing. It is FDA-classified GRAS and pharmacologically inert at the doses used.
The Science
Q: Is there clinical evidence for hydroxyapatite in oral supplements?
Yes, though the majority of studies use hydroxyapatite in toothpaste form. The remineralization mechanism — Ca²⁺ and PO₄³⁻ ion integration into enamel crystal lattice — is well-characterized. A 2022 study in Science Advances demonstrated epitaxial crystal growth using biomimetic calcium phosphate, directly validating the structural mechanism. Clera's use of Microcrystalline Hydroxyapatite Complex in a chewable format applies the same contact-based mineral transfer principle. These statements have not been evaluated by the FDA.
Q: Are oral probiotics actually proven to work?
The literature is robust at the genus and species level; specific strain data varies by strain. Lactobacillus salivarius strains have demonstrated S. mutans biofilm inhibition via glucosyltransferase downregulation in peer-reviewed trials (PMID: 24961744). L. paracasei strains have shown bacteriocin production and coaggregation with oral pathogens. The oral microbiome is real, modifiable, and clinically significant — the evidence base for probiotic influence on it is not hypothetical. These statements have not been evaluated by the FDA.
Q: How is Clera different from just chewing xylitol gum?
Xylitol gum delivers xylitol (one mechanism). Clera delivers xylitol plus Microcrystalline Hydroxyapatite Complex (enamel remineralization), three oral probiotic strains (microbiome modulation), and Guava Fruit Powder (gum tissue antioxidant and anti-inflammatory support). The difference is the number of mechanistic targets addressed simultaneously. These statements have not been evaluated by the FDA.
Safety & Suitability
Q: Is Clera safe for children?
Clera is formulated for adult use. Consult a pediatric dentist or healthcare provider before giving any dietary supplement to a child. Xylitol is generally recognized as safe for children in dentistry-appropriate doses, but individual suitability should be confirmed with a clinician.
Q: Is Clera safe during pregnancy or breastfeeding?
Consult your OB-GYN or midwife before starting any new dietary supplement during pregnancy or while breastfeeding. While the individual ingredients have established safety profiles, we do not conduct pregnancy-specific clinical trials, and your provider is best positioned to evaluate suitability for your individual situation.
Q: Does Clera interact with medications?
No known pharmacological interactions have been identified for the ingredients in Clera at the doses used. However, if you are taking immunosuppressant medications, consult your physician before using any probiotic supplement. As with any supplement, disclose use to your healthcare provider.
Q: Is xylitol safe for people with diabetes?
Xylitol has a low glycemic index (GI ≈ 7, compared to sucrose at 65) and is minimally insulin-stimulating. Many individuals with diabetes use xylitol products routinely. Dietary management in diabetes is individualized — consult your endocrinologist or primary care provider regarding specific suitability.
Q: ⚠️ Is Clera safe for dogs to be around?
Important: xylitol is acutely toxic to dogs. Store Clera in a location inaccessible to pets. Do not allow dogs to ingest Clera under any circumstances. This is a serious veterinary safety concern.
The Brand
Q: Why no fluoride?
Fluoride is effective, well-studied, and the gold standard of enamel protection. Clera is not anti-fluoride — it is an alternative for people who want a fluoride-free oral supplement. You can use Clera alongside fluoride toothpaste; the mechanisms are complementary, not competing.
Q: Why are all ingredient doses disclosed?
Because undisclosed doses are undisclosed for a reason, usually a bad one. If a formula works, its doses are defensible. We disclose every active: 325mg Guava Fruit Powder, 20mg total probiotic blend, 5mg Microcrystalline Hydroxyapatite Complex. That's not unusual transparency — it's baseline transparency that should be standard.
⚠️ FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Clera is a dietary supplement. Individual results may vary. Consult your healthcare provider before use if you are pregnant, nursing, have a medical condition, or are taking any medications.